Kamiren XL Adverse Reactions

Like other alpha-adrenergic receptor antagonists, doxazosin may also cause orthostatic hypotension, particularly at the beginning of treatment. Kamiren XL modified-release tablets allow more uniform plasma doxazosin concentrations without a pronounced peak, so the risk for orthostatic hypotension and for some other undesirable effects is lower than with ordinary tablets. The difficulties usually resolve spontaneously; if they are prolonged or severe, the dose should be reduced or treatment discontinued.
Frequently reported undesirable effects of doxazosin (> 1%) are: Autonomic nervous system: dry mouth.
Body as a whole: asthenia, back pain, chest pain, influenza-like symptoms.
Cardiovascular system: peripheral edema, orthostatic hypotension, hypotension, tachycardia, palpitations.
Central and peripheral nervous system: dizziness, headache, vertigo.
Gastrointestinal tract: abdominal pain, nausea, dyspepsia.
Bones and muscles: myalgia.
Psychiatric disorders: somnolence.
Respiratory tract: bronchitis, cough, respiratory tract infections, rhinitis.
Skin: pruritus.
Urinary tract: urinary tract infections, urinary incontinence.
The following undesirable effects have been reported very rarely: Body as a whole: hypersensitivity reactions, hot flushes, pain, increase in body weight.
Cardiovascular system: hypotension, syncope, bradycardia, angina pectoris, myocardial infarction, cerebrovascular insult, arrhythmias.
Central and peripheral nervous system: hypoesthesia, paresthesia, tremor.
Endocrine glands: gynecomastia.
Gastrointestinal tract: constipation, diarrhea, dyspepsia, flatulence, vomiting.
Hematopoietic system: leukopenia, thrombocytopenia, purpura.
Liver and gall bladder: pathologic liver tests, cholestasis, hepatitis, jaundice.
Bones and muscles: arthralgia, muscle cramps, muscle weakness.
Psychiatric disorders: agitation, worry, depression, excessive tension, insomnia, anorexia.
Respiratory tract: exacerbation of bronchospasm, dyspnea, cough, epistaxis.
Skin: alopecia, skin rash.
Senses: blurred vision, tinnitus.
Urogenital system: hematuria, miction disorders (dysuria, micturition frequency, nocturia), impotence, priapism.
There is no reliable causal relationship between the drug and the previously mentioned undesirable effects. Some undesirable effects were reported only in patients with hypertension and were probably disease-related (e.g. bradycardia, tachycardia, other cardiac arrhythmias, palpitations, chest pain, angina pectoris, myocardial infarctions and cerebrovascular insults). In patients with benign prostatic hyperplasia, the incidence of undesirable effects is similar to that with placebo.
The incidence of undesirable effects in elderly patients is similar to that in younger patients.